Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) (aa 1-100)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human
Isotype
n/a
Format
serum
Size
100 μL
Concentration
n/a
Applications
Immunohistochemistry (IHC),Western Blotting (WB)
Reviews / Ratings
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Description
FUNCTION: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. LOCATION: Cell membrane, Multi-pass membrane protein. Endomembrane system, Multi-pass membrane protein. Endosome membrane, Multi-pass membrane protein. Note: Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin. Tissue specificity: Expressed in platelets (at protein level).Synonyms: Sodium-dependent serotonin transporter, 5HT transporter, 5HTT, Solute carrier family 6 member 4, HTT, SERT
Immunogen
A synthetic peptide from aa region 1-100 of human SLC6A4 conjugated to an immunogenic carrier protein was used as the antigen.