Purity ≥ 95%, as determined by SDS-PAGE and visualized by silver stain. Dectin-2α, also known as CLEC6A, CLECSF10, and NKCL, belongs to the C-type lectin family of transmembrane immune regulatory glycoproteins. Dectin-2α, CLEC4A/DCIR, CLEC4B/DCAR, CLEC4C/DLEC, CLEC4D/MCL, and CLEC4E/mincle constitute a subgroup of these molecules that exhibit approximately 40% aa sequence identity in their extracellular domains (ECD) and have a conserved cysteine spacing in their carbohydrate recognition domains (CRD). 1,2 Mature mouse dectin-2α consists of a short cytoplasmic tail, a transmembrane segment, and an ECD with a stalk region and one CRD. 3,4 Alternate splicing leads to partial deletion of the transmembrane segment and stalk (β isoform) or a portion of the CRD (γ isoform). 4 The full length dectin-2α isoform is a 27 kD molecule that is primarily expressed on the surface of tissue macrophages and their precursors. 3-6 The CRD of dectin-2α contains an