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Description
Rabbit IgG polyclonal Picoband? antibody for PTPN22 detection. Tested with WB, IHC-P, Direct ELISA in Mouse;Rat. No cross reactivity with other proteins. Protein tyrosine phosphatase, non-receptor type 22 (lymphoid), also known as PTPN22, is a protein that in humans is encoded by the PTPN22 gene. This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Immunogen
E. coli-derived mouse PTPN22 recombinant protein (Position: M1-Q309).