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Description
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. Synonyms: Monoclonal BCCIP antibody, Anti-BCCIP antibody, BRCA2 and CDKN1A-interacting protein antibody, TOK-1 antibody.
Immunogen
BCCIP antibody was raised in mouse using recombinant Human Brca2 And Cdkn1 A Interacting Protein (Bccip)