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| Antigenic Specificity | BRCA1 Associated RING Domain 1 (BARD1) |
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| Clone | 2059C4a |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | Protein G purified |
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| Size | 50 μg |
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| Concentration | n/a |
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| Applications | Dot Blot (DB),Immunoprecipitation (IP),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BARD1 interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, BARD1 shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. The BARD1 protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. BARD1 may be the target of oncogenic mutations in breast or ovarian cancer. Synonyms: Monoclonal BARD1 antibody, Anti-BARD1 antibody, BRCA1 associated RING domain gene 1 antibody. |
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| Immunogen | BARD1 antibody was raised in mouse using recombinant Human Brca1 Associated Ring Domain 1 (Bard1) |
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| Other Names | BARD1|LOC100147913|ENSMUSG00000060893|ENSMUSG00000073653 |
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| Gene, Accession # | Gene ID: 580 |
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| Catalog # | ABIN930988 |
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| Price | |
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| Order / More Info | BRCA1 Associated RING Domain 1 (BARD1) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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