Western Blot (WB), Immunofluorescence Microscopy (IF), ELISA
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Description
Purified anti-Hsp90α. Hsp90 is one of the most abundant molecular chaperones. It modulates the stability and transport of a diverse set of critical factors, including regulatory, metabolic, organizational, and signaling proteins. There are two major isoforms: α and β. In humans, the Hsp90β isoform is constitutively expressed, whereas the Hsp90α isoform is expressed under stress conditions. The Hsp90 dimer acts in concert with other chaperones and is regulated by a number of co-chaperones/accessory proteins. Upregulation of Hsp90 is associated with tumor progression, invasion and formation of metastases, and development of drug resistance. Therefore Hsp90 has emerged as an important target for cancer treatment.
Immunogen
Amino acids 702-716 of human HSP90α
Other Names
Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1, HSPC1, HSP86, HSP89A, HSPCAL4, LAP2, EL52 and HSP90N, HSP90a, HSP90 alpha