If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
Lipocalin-2, a member of the lipocalin family of proteins, was originally identified as a gelatinase-associated component of neutrophil secretory granules . Lipocalin-2 is involved in innate immunity, iron homeostasis, and apoptosis. Lipocalin-2 limits bacterial growth by binding to bacterial siderophores and sequestering iron . In mammalian cells, iron-loaded lipocalin-2 binds to its receptor, 24p3R, and is internalized, thereby releasing iron and increasing the intracellular iron concentration . Conversely, iron-free lipocalin-2 promotes apoptosis . Lipocalin-2 is also expressed in adipose tissue and promotes insulin resistance in cultured mouse adipocytes . Synonyms: LCN2, 24p3, MSFI, NGAL, Lipocalin-2,