Control peptide for C7948-50F, polyclonal antibody to CUGBP2. RNA editing is an important mechanism for regulating genetic plasticity through the generation of alternative protein products from a single structural gene. There are two types of substitutional RNA exist in mammals, namely A-to-I and C-to-U RNA editing. The best-characterized example of C-to-U RNA editing involves the nuclear transcript encoding intestinal apolipoprotein B (apo B)). Apo B RNA editing changes a CAA to a UAA stop codon, generating a truncated protein, apoB48. The functional complex includes a minimal core composed of apobec-1 and ACF, that function as an adaptor protein by binding both the deaminase and the RNA substrate. The RNA binding proteins also include CUGBP2 which along with Apobec-1 binds to the consensus binding sequence UUUN (A/U) U, present in c-myc, VEGF and Cyclooxygenase-2 (COX2). Source: Synthetic peptide corresponding to 18aa of human CUGBP2, C-terminal. Molecular Weight: ~3kD Applications:
Size
100ug
Concentration
n/a
Applications
ELISA
Other Names
CUGBP2, Control Peptide (CUGBP Elav-like Family Member 2, CELF-2, Bruno-like Protein 3, CUG Triplet Repeat RNA-binding Protein 2, CUG-BP2, CUG-BP- and ETR-3-like Factor 2, ELAV-type RNA-binding Protein 3, ETR-3, Neuroblastoma Apoptosis-related RNA-binding Protein, hNAPOR, RNA-binding Protein BRUNOL-3, CELF2, BRUNOL3, ETR3, NAPOR)