ILK, Recombinant, Human, aa1-228, His-Tag (Integrin-linked Protein Kinase)
Description
Purity ~90% (SDS-PAGE). Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. Source: Recombinant protein corresponding to aa1-228 from human ILK, fused to His-Tag at N-terminal expressed in E. coli. Molecular Weight: ~30.0kD AA