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Description
Polyclonal Antibody to detect Bad in Human, Mouse, Rat samples. Bad is a member of the Bcl-2 family proteins. Within the Bcl-2 homology domains 1 and 2 (BH1 and BH2), Bad shows significant homology to Bcl-2 and Bcl-x. Bcl-2 is known to block several apoptosis signals and is considered to be a central downstream cell death repressor. Bcl-XL represses apoptosis, but its short form, Bcl-XS, promotes cell death. Bax is known to homodimerize as well as heterodimerize with Bcl-2. An excess concentration of Bax opposes the ability of Bcl-2 to repress cell death. Bad can selectively dimerize with Bcl-xL and Bcl-2, but not with Bax, Bcl-xS, Mcl-1, A1, or itself. In mammalian cells, Bad binds more strongly to Bcl-xL than Bcl-2, which may explain why
Immunogen
Full length human Bad
Other Names
BAD antibody,BAD human antibody,BBC 2 antibody,BBC2 antibody,BBC6 antibody,Bcl 2 Antagonist of Cell Death antibody,Bcl 2 Binding Component 6 antibody,BCL X / BCL 2 Binding Protein antibody,BCL X Binding Protein antibody,Bcl XL/Bcl 2 Associated Death Promoter antibody,Bcl-2-binding component 6 antibody,Bcl-2-like protein 8 antibody,Bcl-XL/Bcl-2-associated death promoter antibody,Bcl2 antagonist of cell death antibody,BCL2 antagonist of cell death protein antibody,BCL2 associated agonist of cell death antibody,Bcl2 Associated Death Promoter antibody,BCL2 binding component 6 antibody,BCL2 binding protein antibody,Bcl2 Like 8 Protein antibody,Bcl2-L-8 antibody,BCL2L8 antibody,BclXL antibody,Proapoptotic BH3 Only Protein antibody.