A selective ligand of RORγ (IC50 = 1 μM); does not bind RORα, LXR, or FXR; acts as an inverse agonist of RORγ, inhibiting endogenous IL-17A gene expression and suppressing differentiation of TH17 cells; stimulates T regulatory development
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
1386439-51-5 retinoic acids receptor-related nuclear γ RORγ g RORg gamma RORgamma .gamma. ROR.gamma. ROR-γ ROR-g ROR-gamma ROR-.gamma. ROR γ T cells differentiations TH17 TH-17 autoimmune diseases multiple sclerosis rheumatoid arthritis MS RA SR1555 development polarizing conditions digoxin ursolic inverse agonists ligands SR-1555 HCl inhibits inhbitors inhibition endogenous IL-17A IL17A IL 17A genes splenocytes mouse mice T-cells