Suppressor of Cytokine Signaling 1 (SOCS1) (aa 2-78)
Clone
4H1
Host Species
Mouse
Reactive Species
mouse
Isotype
IgG1
Format
biotin conjugate
Size
100 μL
Concentration
n/a
Applications
Western Blotting (WB)
Reviews / Ratings
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Description
The Suppressor of Cytokine Signaling (SOCS) family of proteins act in a classic negative feedback loop to regulate cytokine signal transduction. SOCS-1, also designated Janus kinase [JAK] binding protein (JAB), or STAT-induced STAT inhibitor (SSI-1), is a 24 kDa protein containing an SH2 domain. SOCS-1 inhibits both IL-6-induced receptor phosphorylation and STAT activation. SOCS-1 is also induced by and inhibits the signaling action of IL-3, IL-4, LIF, prolactin, and erythropoietin. Additionally, SOCS-1 can associate with all 4 JAK family kinases, and is an important regulator of the JAK-STAT signaling pathway. SOCS-1 is found primarily in thymocytes, where it plays a key role in the negative regulation of IFN- γ signaling and T cell differentiation.Synonyms: JAB, JAK-binding protein, SOCS-1, SSI-1, SSI1, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, TIP-3, TIP3, Tec-interacting protein 3