Purity ~90% (SDS-PAGE). KRT8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. KRT8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Source: Recombinant protein corresponding to human KRT8, fused to His-tag at N-terminal expressed in E.coli. Molecular Weight: ~56kD (506aa) AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMSIRVTQ KSYKVSTSGP RAFSSRSYTS GPGSRISSSS FSRVGSSNFR GGLGGGYGGA SGMGGITAVT VNQSLLSPLV LEVDPNIQAV RTQEKEQIKT LNNKFASFID KVRFLEQQNK MLETKWSLLQ QQKTARSNMD NMFESYINNL RRQLETLGQE KLKLEAELGN MQGLVEDFKN KYEDEINKRT EMENEFVLIK KDVDEAYMNK VELESRLEGL TDEINFLRQL YEEEIRELQS QISDTSVVLS MD
Size
100ug
Concentration
n/a
Applications
n/a
Other Names
KRT8, Recombinant, Human, aa1-483, His-Tag (Keratin Type II Cytoskeletal 8, Keratin 8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO)