An inhibitor of RAGE (Kd = 12.7 nM); selective for sRAGE over greater than 100 receptors and transporters in a screening assay; prevents brain deposition of Aβ40 and Aβ42 and reduces impairments in learning and memory tgAPP/SWE/LON mice at 0.3, 1, and 3 mg/kg per day in aged mice; increases cerebral blood flow in the hippocampus and frontal cortext in tgAPP/SWE/LON mice greater than 6 months old