Recombinant Human Proteasome activator complex subunit 3 (PSME3), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 56.1kDa. Partial: 2-252aa. N-terminal GST-tagged. Homo sapiens (Human). Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.