Cell-permeable. KN-62 is a selective inhibitor of Ca?+/calmodulin-dependent kinase type II (CaMKII; IC50= 900 nM). It binds directly to the calmodulin binding site of the enzyme. It does not affect the activity of several other kinases when tested at 10 μM. KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM). MW: 721.84. Purity ≥98%