Purity > 85% as determined by SDS-PAGE. MW: 78.9kDa. Full Length: 1-656aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Mus musculus (Mouse). Serine-threonine kinase which transduces inflammatory and cell-death signals following death receptors ligation, activation of pathogen recognition receptors, and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death (By similarity). RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Cell death protein RIP (Receptor-interacting protein 1) (RIP-1) (Rinp) (Rip)