Purity > 90% as determined by SDS-PAGE. MW: 55.3kDa. Full Length: 1-486aa. N-terminal 6xHis-tagged. Mus musculus (Mouse). Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family mbers. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
RIP-like protein kinase 3Receptor-interacting protein 3; RIP-3; mRIP3