A diterpenoid furanolactone with diverse biological activities; inhibits the growth of T. brucei in vitro and induces complete parasite clearance in T. brucei-infected mice (25 mg/kg per day for 3 days); selectively inhibits COX-2 over COX-1 (EC50s = 53.1 and 327 μM, respectively); reduces carrageenan-induced paw edema in rats; reduces the number of lesions in a rat model of azoxymethane-induced colon carcinogenesis (4, 20, and 100 ppm, dietary); reduces urethane and reduces sleeping time induced by a mixture of urethane and α-choralose but prolongs hexobarbital-induced sleeping time in mice,