Purity > 85% as determined by SDS-PAGE. MW: 51.7kDa. Full Length of Mature Protein: 23-358aa. N-terminal 6xHis-B2M-tagged. Xenopus laevis (African clawed frog). Ligand for mbers of the frizzled family of seven transmbrane receptors. Plays a role in ventral mesodermal patterning during bryogenesis. Mimics Nieuwkoop center activity. Causes dorsal mesodermal differentiation of animal cap ectoderm when coexpressed with noggin and nuclear, sequence-specific DNA-binding protein xBra. None of these molecules causes dorsal mesoderm formation when expressed alone.