JNK inhibitor (Kd values are 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Inhibits LPS-induced proinflammatory cytokine and nitric oxide production in vitro. Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo. Anti-inflammatory and immunosuppressive. Also releases NO upon metabolism by liver microsomes. Purity 99%. MW (observed): 269.23
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt