Antibiotic LL Z1640-2 (Antibiotic C292, Antibiotic L 783278)
Description
Purity ≥ 95% by HPLC. Antibiotic LL Z1640-2 a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in an animal models. Source: Antibiotic LL Z1640-2 Molecular Weight: ~362.4 Solubility: Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.