serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5 (SERPINA5) (AA 20-406) protein (His tag) from ANTIBODIES-ONLINE GmbH
serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5 (SERPINA5) (AA 20-406) protein (His tag)
Description
SERPINA5 up regulateS TAFI activation by inhibiting the protein C activation. SERPINA5 is an significant regulator in the equilibrium between coagulation and fibrinolysis by differentially inhibiting the activation of TAFI and of Protein-C. SERPINA5 belongs to the serpin serine proteinase inhibitor family. SERPINA5 protein inhibits plasminogen activators as well as activated protein C. SERPINA5 is secreted in plasma and liver. SERPINA5 is involved in cell inflammation, proliferation, apoptosis, tumour cell migration, invasion, and metastasis. SERPINA5 controls the invasive potential of renal cell carcinoma by inhibiting urinary plasminogen activator secreted by the cells. SERPINA5 plays a role in regulating key serine proteases involved in metastatic prostate disease. The heparin binding site of SERPINA5 inhibitor is protease-dependent Synonyms: PAI3, PCI, PROCI, PLANH3, Protein-C Inhibitor, Plasma serine protease inhibitor, Serpin A5, Plasminogen activator inhibitor 3, PAI-3, Acrosomal serine protease inhibitor, SERPINA5