A potent STAT3 activator and neuroprotective agent; protects approximately 50 and 100% of mouse primary cortical neurons from Aβ1-43-induced cell death at 10 and 100 fM, respectively; protects against V642I-APP-induced cell death in a CaMKIV and STAT3-dependent manner; It increases STAT3 phosphorylation in vitro and in vivo; rescues spatial working memory deficits in a mouse model of Alzheimer's disease at 10 pmol every six days