Purity > 90% as determined by SDS-PAGE. MW: 40.9kDa. Full Length of Mature Protein: 2-129aa. N-terminal GST-tagged. Homo sapiens (Human). Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a tplate. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome rodeling.