Recombinant Human Programmed cell death protein 6 (PDCD6)
Description
Purity > 90% as determined by SDS-PAGE. MW: 48.9kDa. Full Length: 1-191aa. N-terminal GST-tagged. Homo sapiens (Human). Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca2+-regulated signals along the death pathway. Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Ses to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca2+ affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5.5 Publications
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Apoptosis-linked gene 2 protein; Probable calcium-binding protein ALG-2