T regulatory (Treg) cells are a subset of T lymphocytes which is characterized by CD4+/CD25+/FOXP3+. These naturally occurring Treg cells originate in the thymus, and comprise 2-10% of peripheral CD4+ T cells. It has been shown that Treg cells are able to inhibit T cells proliferation and cytokine production and play critical roles in preventing autoimmunity as well as in controlling tumor immunity and transplantation tolerance. Impaired Treg function or Treg cell deficiency will develop variety of autoimmune diseases, while higher frequency of Treg cells will cause hypo-immune response to pathogens.BioLegend's True-Nuclear? Human Treg Flow? Kit is designed and formulated specifically for immunofluroscence staining and flow cytometric analysis of human Treg cells in a mixed lymphocyte population. This kit is composed of fluorochrome conjugated anti-human CD4, CD25, FOXP3 antibodies, and the critical buffers. It is easy to use for identification of Treg cells.
Size
25 tests
Concentration
Flow Cytometry (FC), Intracellular Staining for Flow Cytometry (ICFC)