Recombinant Human Bifunctional polynucleotide phosphatase/kinase (PNKP)
Description
Purity > 90% as determined by SDS-PAGE. MW: 73.1kDa. Full Length: 1-521aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either roving 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.