Purity > 90% as determined by SDS-PAGE. MW: 70.7kDa. Full Length of Isoform 3: 1-476aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Farnesoid X-activated receptorFarnesol receptor HRR-1Nuclear receptor subfamily 1 group H member 4Retinoid X receptor-interacting protein 14; RXR-interacting protein 14