If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
Rabbit Anti-Human TP53BP1 polyclonal antibody for WB. Tumor suppressor p53-binding protein 1 (also known as 53BP1, p202, p53-binding protein 1, p53BP1) is encoded by the TP53BP1 gene (Entrez Gene ID 7158) in human. 53BP1 is a multidomain nonhomologous end joining (NHEJ) factor involved in the repair of double-strand DNA breaks (DSBs). The minimal region (residues 1,220-1,711) required for its recruitment includes the oligomerization domain, the tudor domain, and a carboxy-terminal extension termed the ubiquitination-dependent recruitment (UDR) motif. However, 53BP1 function must be inactivated during mitosis to prevent its interference with homologous recombination (NR). 53BP1 inactivation during mitosis is shown to be achieved by p38-dependent pT1609 and PLK-1-dependent pT1618 phosphorylation within the UDR motif. Reactivating 53BP1 function results in severe mitotic defects.
Immunogen
Linear peptide corresponding to human phospho-53BP1 (Thr1609/Ser1618).