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Description
Rabbit Anti-Human TPO polyclonal antibody for IHC, ICC. Thyroid peroxidase (TPO) is a membrane-bound glycoprotein that acts as an enzyme and plays a central role in thyroid gland function. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. TPO is localized to the membrane. Mutations in TPO are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.