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Description
Rabbit Anti-Human PPP1R15A polyclonal antibody for IHC. Protein phosphatase 1 regulatory subunit 15A, also known as, Growth arrest and DNA damage-inducible protein GADD34 or Myeloid differentiation primary response protein MyD116 homolog, and encoded by the gene name(s), PPP1R15A or GADD34, can be triggered as a direct target of activating transcription factor4 (ATF4) under ER stress. PPP1R15A plays a pivotal role in the recovery of cells from shut-down of translation induced by ER stress. It recruits the serine/threonine-protein phosphatase (PP1) to dephosphorylate the translation initiation factor eIF2alpha, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress.