peptide-ELISA: 1:32000, Western Blot: 0.3-1.0 μg/mL
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Description
TIM3 Polyclonal Antibody. TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 depe
Immunogen
n/a
Other Names
HAVCR2; TIM3; hepatitis A virus cellular receptor 2; FLJ14428; KIM-3; TIMD3; Tim-3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; kidney injury molecule-3