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Description
Rabbit Anti-Rat SEPT11 polyclonal antibody for WB, IHC. Septin-11 is encoded by the Sept11 gene in rat and mouse (SEPT11 in human). Septins are GTP-binding proteins capable of forming higher-order oligomers and filamentous polymers that contact with the cell membrane and cytoskeleton. Septins are involved in various cellular processes, including cytokinesis, karyokinesis, exocytosis, and cell shape maintenance. Evidence indicates that septin-11 plays important roles in the cytoarchitecture of rat brain neurons, including dendritic arborization and dendritic spines, as well as in GABAergic synaptic connectivity. Septin-11 is also reported to be involved in host defense against Listeria surface protein InlB-mediated invasion in non-phagocytic cells in human. In addition, Septin-11 is identified to be enriched in the detergent-insoluble protein extracts prepared from frontal cortex of FTLD-U (frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions) patients.
Immunogen
KLH-conjugated linear peptide corresponding to the N-terminal sequence of rat Septin 11.