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Description
Mouse Anti-Human C10ORF81 polyclonal antibody for WB. Diphtheria is a bacterial infectious disease which appears predominantly during the childhood. The disease leads particularly to an inflammation of the pharynx, larynx and nasal mucosa. The etiologic agent is the Corynebacterium diphtheriae. Its pathogenicity is based on the secretion of an exotoxin that is circulating in the blood and effecting the heart muscle, kidneys and CNS. Only the toxigenic strains are pathogenic. Depending on the stage of disease, the three types 'slight, middle and serious' can be distinguished. The grade of disease depends on the immune status of the child. Usually, a limited Diphtheria arises, whereas in case of an immune suppression, a severe Diphtheria is observed. As a result of this course of disease, the patient may die. In most cases children will be vaccinated (e.g. DTP = Diphtheria-Tetanus-Pertussis) after the third month of life. The state of immunity can be monitored by determining the antitoxin IgG.
Immunogen
Partial human C10orf81 protein (AAH36365, amino acids 14-268 or Q5SXH7, amino acids 181-435).