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Description
Rabbit Anti-Human INSR (phospho Tyr1158) monoclonal antibody for FC, WB. Insulin receptor (IR), belongs to the growth factor receptor tyrosine kinase superfamily which regulates multiple signaling pathways. It is a heterotetrameric membrane glycoprotein consisting of alpha and beta subunits encoded by the INSR gene in humans. IR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in IR. In humans, the IR gene is located on chromosome 19.
Immunogen
Phosphopeptide corresponding to amino acids 1153-1162 of human insulin receptor