Immunohistochemistry: 1:1,000-1:5,000, Immunoprecipitation: 2-10 μg/mg lysate, Western Blot: 1:2,000-1:10,000
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Description
ARS2 Polyclonal Antibody. Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and RNASEN, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.
Immunogen
n/a
Other Names
ARS2, ASR2, serrate, arsenate resistance protein 2, arsenate resistance protein ARS2, arsenite resistance protein, arsenite-resistance protein 2, serrate RNA effector molecule homolog