Immunocytochemistry: 1:10-1:200, Immunofluorescence: 1:10-1:200, Western Blot: 2 μg/mL
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Description
BACE2 Polyclonal Antibody. BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.
Immunogen
n/a
Other Names
BACE2, Beta-Site APP-Cleaving Enzyme 2, Aspartyl protease 1, Asp 1, ASP1, Membrane-associated aspartic protease 1, Memapsin-1, Down region aspartic pr