Immunocytochemistry: 1:10-1:50, Immunofluorescence: 1:10-1:50, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 1:1000
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Description
ACOX1 Monoclonal Antibody (153CT43.1.1). The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.