Purity >98% by SDS-PAGE gel and HPLC analyses., MW: 16.9 kDa. The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36a (IL-1F6), IL-36β (IL-1F8), and IL-36? (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-?B signaling induced by either IL-36a, β or ? by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant Murine IL-36RA is an E.coli-derived 16.9 kDa protein containing 154 amino acid residues.
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Other Names
IL36RN, FIL1, FIL1D, IL-1 delta, IL-1 related protein 3, IL-1HY1, IL-1RP3, IL-1-related protein 3, IL1F5, IL1RP3, IL1L1, IL36RA, Interleukin-1 delta, Family of interleukin 1-delta, FIL1 delta, IL-1L1, IL-1ra homolog 1, Interleukin-1 family member 5, Interleukin-1-like protein 1, FIL1(DELTA), IL-1F5, IL1HY1, Interleukin-1 HY1, PSORP