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Description
Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.Subunit: Homotetramer or heterotetramer with other ASIC proteins (Probable). Interacts with STOM and DLG4. Interacts with LIN7B, MAGI1/BAIAP1, GOPC and ACCN1.Subcellular location: Cell membrane, Multi-pass membrane protein. Cytoplasm. Note: Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells.Tissue specificity: Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.Developmental stage: Expressed in fetal tissues, expression increases in lung and kidney adult tissues. Also known as: Amiloride-sensitive cation channel 3, Acid-sensing ion channel 3, ASIC3, hASIC3, Testis sodium channel 1, hTNaC1, TNaC1, SLNAC1, ACCN3, TNAC1.
Immunogen
A synthetic peptide from aa region 450-490 of human ASIC3 conjugated to blue carrier protein was used as the antigen.