Purity ~95% (SDS-PAGE). The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family (NLRs), including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA). Pyrin domain-containing protein 1 (POP1) interacts with the protein Asc (Pycard) and modulates the interaction of Asc to NLR proteins. Source: Recombinant protein corresponding to aa2-89 from human POP1, fused to a GST-tag at N-terminal, expressed in E. coli. Molecular Weight: ~38kD
Size
10ug, 3x10ug
Concentration
n/a
Applications
n/a
Other Names
POP1, Recombinant, Human, aa2-89, GST-Tag (Pyrin Domain-containing Protein 1, PAAD-only Protein 1, Pyrin-only Protein 1, ASC2, ASCI, PYDC1, PYC1)