Purity ~90% (SDS-PAGE). Neuroblastoma suppressor of tumorigenicity 1, also known as NBL1, is a member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. NBL1 is a candidate as a tumor suppressor of neuroblastoma and may play a role in preventing cells from entering the final stage (G1/S) of the transformation process. It is produced in small neurons of the dorsal root ganglion and its expression is activated by MATH-1. Source: Recombinant protein corresponding to human NBL1, fused to His-tag at N-terminal expressed in E.coli. Molecular Weight: ~20kD (187aa) (MALDI-TOF) AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSAPPPINK LALFPDKSAW CEAKNITQIV GHSGCEAKSI QNRACLGQCF SYSVPNTFPQ STESLVHCDS CMPAQSMWEI VTLECPGHEE VPRVDKLVEK ILHCSCQACG KEPSHEGLSV YVQGEDGPGS QPGTHPHPHP HPHPGGQTPE PEDPPGAPHT EEEGAED
Size
100ug
Concentration
n/a
Applications
n/a
Other Names
NBL1, Recombinant, Human, aa18-181, His-Tag (Neuroblastoma Suppressor of Tumorigenicity 1, D1S1733E, DAN, DAND1, NB, NO3)