Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. Description: Skeletal Muscle. Alternative Names: Troponin I protein, Skeletal Muscle Troponin I protein, TnI protein, Skeletal-specific troponin I protein, sTnl protein