A TRP1 antagonist (IC50 = 0.9 nM); inhibits mechanical and thermal allodynia in a rat model of burn injury at 165 μg, intrathecally; reverses increases in the level of CGRP and increases expression of GFAP and GAP-43 in the dorsal horn of the spinal cord, as well as enhances axonal regeneration in a rat model of sciatic nerve transection injury