Fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II. FGL1 inhibits antigen-specific T cell activation, and ablation of FGL1 in mice promotes T cell immunity. Blockade of the FGL1-LAG-3 interaction by monoclonal antibodies stimulates tumor immunity and is therapeutic against established mouse tumors in a receptor-ligand inter-dependent manner.
Size
200μg
Concentration
0.6mg/mL
Applications
n/a
Other Names
Fibrinogen-like protein 1 (human), HFREP1 Protein, Human; HP-041 Protein, Human; LFIRE-1 Protein, Human; LFIRE1 Protein, Human