Western Blot (WB), IHC, IP, Immunofluorescence Microscopy (IF), ELISA
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Description
Purified anti-Blimp-1. Blimp-1 is a 98 Kd protein containing five Kuppel-type zinc finger domains that confer sequence specific DNA binding.? It has been postulated to be a master regulator of terminal B cell differentiation. In the BCL-1 lymphoma model of differentiation from mature B cells to plasma cells, ectopic expression of Blimp-1 is sufficient to cause terminal differentiation manifested by loss of surface immunoglobulin, IgM secretion, expression of syndecan-1 and cessation of cell division. Recently, it is reported that Blimp-1 is also involved in T cell differentiation and T cell homeostasis and suppression of IL-2 production.
Immunogen
Recombinant GST-blimp-1 protein
Other Names
B lymphocyte-induced maturation protein-1, PRDM-1, BLIMP1