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Description
LITAF Polyclonal Antibody. Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this
Immunogen
n/a
Other Names
PIG7, SIMPLE, TP53I7, LPS-induced TNF-alpha factor, lipopolysaccharide-induced TNF-alpha factor, lipopolysaccharide-induced tumor necrosis factor-alpha factor, p53-induced gene 7 protein, small integral membrane protein of lysosome/late endosome, tumor protein p53 inducible protein 7