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Description
Mouse monoclonal to CD86.T-lymphocyte activation antigen CD86 is a receptor involved in the costimulatory signal essential forT-lymphocyte proliferation and interleukin-2 production. CD86 binds to CD28 or CTLA-4 and may playa critical role in the early events of T-cell activation and costimulation of naive T-cells, such asdeciding between immunity and anergy. CD86 isoform 2 interferes with the formation of CD86 clusters,and thus acts as a negative regulator of T-cell activation.