A serotonin and norepinephrine reuptake inhibitor (Kis = 4.6 and 15.6 nM, respectively); also inhibits dopamine reuptake (Ki = 369 nM); suppresses spontaneous firing activity in vivo in the dorsal raphe and locus coeruleus (ED50s = 99 and 475 μg/kg, respectively); has antidepressant-like activity in mice in the forced swim test at 16 and 32 mg/kg